Fiber Optic Biosensors

Using the same theory and phenomena as the whispering gallery mode imaging project, we hope to expand the applications of WGM imaging by investigating biosensors made of optical fibers and microresonators. Currently, we are exploring the use of fiber optic based prisms for launching WGMs in fluorescently coated microsphere resonators. Preliminary results indicate the ability of the biosensors to detect tumor necrosis factor-alpha (TNF-α), a biomarker for ovarian cancer.

S1 Image
Figure 1. Microresonator on a polished fiber optic allows for whispering gallery mode imaging for biosensor applications.

Additionally, we would like to incorporate multiplexed detection by integrating fiber optic bundles with microresonators. This would provide a platform for multiplexed detection and sensing. Benefits of the sensor design include small sample size and remote sensing of dangerous or isolated locations.

S2 Image
Figure 2. Schematic of multiplexed fiber optic biosensor design using whispering gallery mode imaging for detection.

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